Farmakokinetik aspirin pdf free

Which aspirin dose is best to protect patients with heart. Aspirin has been studied in more than 1,000 patients and is recommended in multiple polycythemia vera guidelines barbui 2006, landolfi 2004, mcmullin 2005. Farmakokinetik klinik fenitoin ft taofik rusdiana ddddept of pharmaceutics, ffup 2. An introduction to aspirin, nsaids, and cox2 inhibitors. Nociceptor ini juga terdapat di seluruh jaringan dan organ tubuh, terkecuali di ssp. Specific inflammatory conditions which aspirin is used to treat include kawasaki disease, pericarditis, and rheumatic fever. The lipid solubility of a drug can effect the diffusion that will occur across the membrane. Clopidogrel winthrop plus aspirin contains the medicines clopidogrel and aspirin. Pdf profil farmakokinetika aspirin pada plasma tikus. Winner of the standing ovation award for best powerpoint templates from presentations magazine. An introduction to aspirin, nsaids, and cox2 inhibitors for. Pdf profil farmakokinetika aspirin pada plasma tikus putih. Scribd is the worlds largest social reading and publishing site.

Pdf on jun 30, 2015, vidia prajna lakhsita and others published profil farmakokinetika aspirin pada plasma tikus putih jantan find, read and cite all the research you need on researchgate. Antiinflammatory inhibition of the synthesis of prostaglandins. Jul 09, 20 pada tikus ii, sebagai tikus uji, mendapat perlakuan yakni pemberian oral aspirin, lalu 6 0 menit kemudian disuntikkan karagenan secara subkutan lalu diamati setiap 1 5 menit selam a 75 menit. The purpose of this experiment is to synthesize aspirin acetyl salicylic acid from salicylic acid and acetic anhydride the purity of the product is tested using the melting point, thin layer chromatography, and highperformance. Aspirin acetylsalicylic acid most common salicylate analgesic is a modification of the salicylic acid found in willow bark. Interaksi farmakokinetik free download as powerpoint presentation. Capitals indicate lifethreatening, underlines indicate most frequent. Food effects absorptionabsorption can be reduced by the presence of food in the gut absorption can be enhanced by food bile secretion some drugs are irritating and should be administered with meals to reduce adverse effects. Farmakokinetik merupakan cabang ilmu farmakologi yang dapat menerangkan. Farmakokinetik ialah apa yang dialami obat yang diberikan pada suatu makhluk, yaitu absorpsi, distribusi, biotransformasi, dan ekskresi. By preventing this clumping, antiplatelet medicines reduce the chances of blood clots. Aspirin wikipedia bahasa indonesia, ensiklopedia bebas.

Nonnarcotic pain relievers aspirin acetylsalicylic acid. Farmakologi terutama terfokus pada 2 subdisiplin, yaitu farmakodinamik dan farmakokinetik. A comparative pharmacokinetic study of aspirin suppositories. Pdf on jun 30, 2015, vidia prajna lakhsita and others published profil farmakokinetika aspirin pada plasma tikus putih. Aspirin is quite lipid soluble having a log p value, which is 1. Pada tikus ii, sebagai tikus uji, mendapat perlakuan yakni pemberian oral aspirin, lalu 6 0 menit kemudian disuntikkan karagenan secara subkutan lalu diamati setiap 1 5 menit selam a 75 menit. Aborsi atau keguguran, akibat misoprostol, obat yang digunakan untuk pencegahan gastric ulcer borok lambung yang disebabkan oleh obat anti inflamasi non steroid. Find patient medical information for valproic acid as sodium salt oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Aspilet merupakan salah satu nama obat paten dari aspirin. Synthesis of aspirin ryan and jose 021214 abstract.

G6pd deficiency and in those who are allergic to aspirin. Thus, it seems as if aspirin, nsaids, and even the selective cox2 inhibitors may have therapeutic potential far beyond reducing pain and general inflammation. It is rapidly biotransformed with a serum half life of 1. Aspirin termasuk dalam kategori obat nonsteroidal antiinflammatory drug nsaid. Sehingga dalam perhitungan persentase efektifitasnya dapat dilihat bahwa efektifitas analgetik parasetamol terhadap aspirin sebesar 21 % dan efektifitas analgetik asam mefenamat terhadap aspirin sebesar 26,8 %. The sponsor plx pharma plx submitted the present nda for the new aspirin formulation designated pl2200. Contoh eso kerusakan janin, akibat thalidomide dan accutane ketagihan, akibat obatobatan penenang dan analgesik seperti diazepam serta morfin.

Call toll free 18889520050 monday through friday 9am5pm health a2z aspirin is not manufactured or distributed by bayer consumer care, distributor of bayer manufactured for. Aspirin chemie referat by moritz gaertner on prezi. Laporan praktikum pengujian efek antiinflamasi farmakologi. Pharmacokinetic study of aspirin in healthy female volunteers. The pharmacokinetic behaviour of acetylsalicylic acid is determined by phdependent dissolution in the stomach, absorption within the upper small intestine and subsequent rapid hydrolysis to salicylic acid, a metabolite that is active with respect to analgetic and antiphlogistic effects, but inactive with regard to inhibition of platelet thromboxane formation. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect. One of the most consumed drugs production in the us is 10 million kgyear aspirin. The results from this trial could improve care for more than 15 million atrisk people. A low dose ibuprofen is as effective as aspirin and paracetamol for the indications normally treated with over the counter medications. Ambreen ijaz, haq nawaz bhatti, saba rasheed, bazghah sadaf and rakhshanda nawaz keywords. Aspirin is in the family of nonsteroidal antiinflammatory drugs otherwise known as nsaids medicines. This article reveals about use of aspirin as antirheumatoid drugs and why therapeutic. Voltaren diclofenac sodium entericcoated tablets is contraindicated in patients with known hypersensitivity to diclofenac. Mar 05, 20 aspirin sebagai anggota dari obat ains anti inflamasi non steroid di dalam tubuh akan mengalami proses absorpsi, distribusi, metabolisme dan eliminasi sebagai suatu proses kesatuan yang disebut farmakokinetik.

Daily administration of low dose 81 mg aspirin, initiated between 6 07 weeks and 67. Aspirin is also used longterm to help prevent further heart attacks, ischaemic strokes. Aspirin asa was developed in 1897 and is one of the most widely used drugs in the world, with an estimated 100 billion tablets taken per year. Aspilet, efektif cegah gangguan jantung infark miokard. Aspirin, also known as acetylsalicylic acid asa, is a medication used to reduce pain, fever, or inflammation. Aspirin sebagai anggota dari obat ains anti inflamasi non steroid di dalam tubuh akan mengalami proses absorpsi, distribusi, metabolisme dan eliminasi sebagai suatu proses kesatuan yang disebut farmakokinetik. Nonnarcotic pain relievers work peripherally at the site of injured cells. Semua senyawa nyeri mediator nyeri seperti histamine, bradikin, leukotrien dan prostaglandin merangsang reseptor nyeri di ujungujung saraf bebas di kulit, mukosa serta jaringan lain dan demikian menimbulkan antara lain reaksi radang dan kejangkejang. Aspirin juga menghambat sintesa tromboksan a2 txa2 di dalarn trombosit, sehingga akhirnya menghambat agregasi trombosit. Aspirin given shortly after a heart attack decreases the risk of death. Jan 05, 2020 aspirin may be used in all patients with polycythemia vera without a history of major bleeding or gastric intolerance.

Metabolisme di hati, sekitar 3 % diekskresi dalam bentuk tidak berubah melalui urin dan 8090 % dikonjugasi dengan asam glukoronik atau asam sulfurik kemudian diekskresi melalui. Farmakokinetik klinik fenitoin linkedin slideshare. Feb 18, 2012 contoh eso kerusakan janin, akibat thalidomide dan accutane ketagihan, akibat obatobatan penenang dan analgesik seperti diazepam serta morfin. Recent evidence shows a cns action as well even on emotional. Aspirin supplementation for pregnancy indicated risk. Sangat larut yaitu sebuah zat obat dianggap sangat larut ketika kekuatan dosis tertinggi yang larut dalam 90% dari dosis yang diberikan, berdasarkan pada keseimbangan massa atau yang bioekivalensi dapat dinilai berdasarkan pada uji disolusi in vitro. Aspirin asam asetil salisilat obat anti radang bukan steroid atau yang lazim dinamakan non streroidal anti inflammatory drugs nsaids atau anti inflamasi non steroid oains adalah golongan obat yang bekerja terutama di perifer yang berfungsi sebagai analgesik pereda nyeri, antipirektik penurun panas dan antiinflamasi anti radang. Aspirin menginaktivasi enzimenzim pada trombosit tersebut secara permanen. Therapeutic drug monitoring tdm pada penggunaan aspirin. Aspirin aspirin dan obat lain ibuprofen, naproxen dll merupakan asam lemah menghambat biosintesis prostaglandin mungkin menurunkan produksi radikal bebas dan superoksida efektif dalam menghambat inflamasi tidak memiliki bukti yg kuat ttg efek merubah perjalanan penyakitgangguan sendi.

This makes aspirin easier to leave the bloodstream and enter the capillaries. Nsaid memiliki efek antiinflamasi, analgesik, dan antipiretik, serta dapat menghambat agregasi trombosit. Clinicians must consider the potential risk for bleeding and. Kecepatan metabolisme dapat menentukan intensitas dan masa kerja obat. Penghambatan inilah yang mempakan cara kerja aspirin dalam pencegahan stroke dan tia transient ischemic attack. Metabolizma hizi, karaciger kan akim hizinin karacigere giren ve cikan kandaki ilac konsantrasyon farki ile carpilmasi ile hesaplanabilir. Gastroprotektif vs kardiotoksik majority volume 6 nomor 3 juli 2017 153. Pemberian obatobatan anti inflamasi non steroid ains pada anak. Jumlah metabolit ditentukan oleh kadar dan aktivitas enzim yang berperan dalam proses metabolisme. Route onset peak duration aspirin pirin po 530min 1. Farmakodinamik aspirin bekerja melalui inhibisi enzim siklooksigenase 1 dan 2 cox1 dan cox2 secara ireversibel, sehingga menurunkan.

This otc medicine monograph outlines the requirements for australian market authorisation of tablets containing aspirin as a single active ingredient when applied for as an otc new medicine n2 application. Metabolisme obat secara normal melibatkan lebih dari satu proses kimiawi dan enzimatik sehingga menghasilkan lebih dari satu metabolit. Discover everything scribd has to offer, including books and audiobooks from major publishers. Pendahuluan phenytoin is a hydantoin compound related to the barbiturates that are used for the treatment of seizures. Which aspirin dose is best to protect patients with heart disease. The present submission is a 505b2 application and uses a monograph aspirin as the reference.

Parasetamol cepat diabsorbsi dari saluran pencernaan, dengan kadar serum puncak dicapai dalam 3060 menit. Jul 10, 20 sedangkan besarnya daya proteksi parasetamol lebih kecil dari besarnya daya proteksi aspirin. Platelets are very small blood cells which clump together during blood clotting. Interaksi dalam proses farmakokinetik, yaitu absorpsi, distribusi, metabolisme dan ekskresi adme dapat meningkatkan ataupun menurunkan kadar plasma obat. These overall observations and effects provided some of the. Pdf aspirin is a nonsteroidal antiinflammatory drug with potential as antiplatelet for stroke prophylaxis. Voltaren should not be given to patients who have experienced asthma, urticaria, or other allergictype reactions after taking aspirin or other nsaids. Interaksi farmakokinetik aspirin pharmaceutical sciences. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. Clopidogrel winthrop plus aspirin belongs to a group of medicines called antiplatelet medicines. May 07, 2020 turmeric is a popular rootspice, and curcumin is a highly potent chemical in turmeric, but hardly the only one. Kecepatan metabolisme ini kemungkinan berbedabeda pada masingmasing. Aspirin may also have some applicability for reducing side effects of oral estrogens in men with advanced prostate cancer. Thus, aspirin, or perhaps salicylate, may have another important pharmacological activity that is separate from the cyclooxygenase inhibitory activity that is common to aspirin and other nsaids.

Find patient medical information for ketotifen ophthalmic eye on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Ibuprofen is supplied as tablets with a potency of 200 to 800 mg. Structural biochemistryaspirin wikibooks, open books. Therapeutic drug monitoring market expected to reach 2. Pdf profil farmakokinetika aspirin pada plasma tikus putih jantan.

It is believed to have been first used in 400 bc by the greek physician hippocrates who would prescribe the bark and leaves of the willow tree to his patients to relieve pain and fever. Bu, farmakokinetik calismalarda, bir organdaki metabolizma veya doku tutulumunun analizinin yapilmasinda genel bir yaklasimdir. Pharmacokinetic study of aspirin in healthy female volunteers author. Aspirin atau asam asetilsalisilat asetosal adalah sejenis obat turunan dari salisilat yang sering digunakan sebagai senyawa analgesik penahan rasa sakit. Lowdose aspirin, as prescribed by your doctor for specific medical reasons such as heart attack or stroke prevention usually these dosages are 825 milligrams per day, should be continued. Acetylsalicylic acid, female volunteers, pharmacokinetics, salicylates, aspirin, volume of distribution, peak plasma concentration, absorption rate constant, half life created date.